|
Mixed Effects Model for log CD4 adjusting for Age and Gender |
|
AIDS Clinical Trial Group (ACTG) 193A Study |
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The Mixed Procedure |
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Model Information |
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Data Set |
WORK.CD4 |
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Dependent Variable |
logcd4 |
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Covariance Structure |
Unstructured |
|
Subject Effect |
id |
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Estimation Method |
REML |
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Residual Variance Method |
Profile |
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Fixed Effects SE Method |
Model-Based |
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Degrees of Freedom Method |
Containment |
|
Class Level Information |
||
|
Class |
Levels |
Values |
|
id |
1309 |
not printed |
|
Dimensions |
|
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Covariance Parameters |
7 |
|
Columns in X |
6 |
|
Columns in Z Per Subject |
3 |
|
Subjects |
1309 |
|
Max Obs Per Subject |
9 |
|
Observations Used |
5036 |
|
Observations Not Used |
0 |
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Total Observations |
5036 |
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Iteration History |
|||
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Iteration |
Evaluations |
-2 Res Log Like |
Criterion |
|
0 |
1 |
14945.60382098 |
|
|
1 |
3 |
11927.68281663 |
0.00053696 |
|
2 |
1 |
11926.92749395 |
0.00000323 |
|
3 |
1 |
11926.92313786 |
0.00000000 |
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Convergence criteria met. |
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Estimated G Matrix |
|||||
|
Row |
Effect |
id |
Col1 |
Col2 |
Col3 |
|
1 |
Intercept |
1 |
0.5814 |
0.007043 |
-0.01213 |
|
2 |
week |
1 |
0.007043 |
0.000923 |
-0.00092 |
|
3 |
week_16 |
1 |
-0.01213 |
-0.00092 |
0.001234 |
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Estimated G Correlation Matrix |
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|
Row |
Effect |
id |
Col1 |
Col2 |
Col3 |
|
1 |
Intercept |
1 |
1.0000 |
0.3040 |
-0.4529 |
|
2 |
week |
1 |
0.3040 |
1.0000 |
-0.8588 |
|
3 |
week_16 |
1 |
-0.4529 |
-0.8588 |
1.0000 |
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Covariance Parameter Estimates |
|||||
|
Cov Parm |
Subject |
Estimate |
Standard Error |
Z Value |
Pr Z |
|
UN(1,1) |
Id |
0.5814 |
0.03462 |
16.79 |
<.0001 |
|
UN(2,1) |
Id |
0.007043 |
0.001803 |
3.91 |
<.0001 |
|
UN(2,2) |
Id |
0.000923 |
0.000160 |
5.75 |
<.0001 |
|
UN(3,1) |
Id |
-0.01213 |
0.002724 |
-4.45 |
<.0001 |
|
UN(3,2) |
Id |
-0.00092 |
0.000236 |
-3.89 |
<.0001 |
|
UN(3,3) |
Id |
0.001234 |
0.000394 |
3.13 |
0.0009 |
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Residual |
|
0.3062 |
0.01007 |
30.39 |
<.0001 |
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Fit Statistics |
|
|
-2 Res Log Likelihood |
11926.9 |
|
AIC (smaller is better) |
11940.9 |
|
AICC (smaller is better) |
11940.9 |
|
BIC (smaller is better) |
11977.2 |
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Solution for Fixed Effects |
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|
Effect |
Estimate |
Standard Error |
DF |
t Value |
Pr > |t| |
|
Intercept |
2.6457 |
0.1280 |
1306 |
20.67 |
<.0001 |
|
age |
0.009993 |
0.003016 |
1534 |
3.31 |
0.0009 |
|
sex |
-0.09269 |
0.07537 |
1534 |
-1.23 |
0.2190 |
|
week |
-0.00717 |
0.001934 |
1186 |
-3.71 |
0.0002 |
|
week_16 |
-0.01243 |
0.002870 |
1004 |
-4.33 |
<.0001 |
|
trt*w16 |
-0.02632 |
0.003429 |
1534 |
-7.68 |
<.0001 |