|
Mixed Effects Model for log CD4 |
|
AIDS Clinical Trial Group (ACTG) 193A Study |
|
The Mixed Procedure |
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Model Information |
|
|
Data Set |
WORK.CD4 |
|
Dependent Variable |
logcd4 |
|
Covariance Structure |
Unstructured |
|
Subject Effect |
id |
|
Estimation Method |
REML |
|
Residual Variance Method |
Profile |
|
Fixed Effects SE Method |
Model-Based |
|
Degrees of Freedom Method |
Containment |
|
Class Level Information |
||
|
Class |
Levels |
Values |
|
id |
1309 |
not printed |
|
Dimensions |
|
|
Covariance Parameters |
7 |
|
Columns in X |
5 |
|
Columns in Z Per Subject |
3 |
|
Subjects |
1309 |
|
Max Obs Per Subject |
9 |
|
Observations Used |
5036 |
|
Observations Not Used |
0 |
|
Total Observations |
5036 |
|
Iteration History |
|||
|
Iteration |
Evaluations |
-2 Res Log Like |
Criterion |
|
0 |
1 |
14981.51659156 |
|
|
1 |
3 |
11935.53693907 |
0.00040624 |
|
2 |
1 |
11934.96765938 |
0.00000185 |
|
3 |
1 |
11934.96517062 |
0.00000000 |
|
Convergence criteria met. |
|
Estimated G Matrix |
|||||
|
Row |
Effect |
id |
Col1 |
Col2 |
Col3 |
|
1 |
Intercept |
1 |
0.5857 |
0.007254 |
-0.01235 |
|
2 |
week |
1 |
0.007254 |
0.000923 |
-0.00092 |
|
3 |
week_16 |
1 |
-0.01235 |
-0.00092 |
0.001240 |
|
Estimated G Correlation Matrix |
|||||
|
Row |
Effect |
id |
Col1 |
Col2 |
Col3 |
|
1 |
Intercept |
1 |
1.0000 |
0.3120 |
-0.4581 |
|
2 |
week |
1 |
0.3120 |
1.0000 |
-0.8584 |
|
3 |
week_16 |
1 |
-0.4581 |
-0.8584 |
1.0000 |
|
Covariance Parameter Estimates |
|||||
|
Cov Parm |
Subject |
Estimate |
Standard Error |
Z Value |
Pr Z |
|
UN(1,1) |
id |
0.5857 |
0.03475 |
16.85 |
<.0001 |
|
UN(2,1) |
id |
0.007254 |
0.001805 |
4.02 |
<.0001 |
|
UN(2,2) |
id |
0.000923 |
0.000160 |
5.76 |
<.0001 |
|
UN(3,1) |
id |
-0.01235 |
0.002730 |
-4.52 |
<.0001 |
|
UN(3,2) |
id |
-0.00092 |
0.000236 |
-3.90 |
<.0001 |
|
UN(3,3) |
id |
0.001240 |
0.000395 |
3.14 |
0.0008 |
|
Residual |
|
0.3062 |
0.01007 |
30.39 |
<.0001 |
|
Fit Statistics |
|
|
-2 Res Log Likelihood |
11935.0 |
|
AIC (smaller is better) |
11949.0 |
|
AICC (smaller is better) |
11949.0 |
|
BIC (smaller is better) |
11985.2 |
|
Solution for Fixed Effects |
|||||
|
Effect |
Estimate |
Standard Error |
DF |
t Value |
Pr > |t| |
|
Intercept |
2.9415 |
0.02562 |
1308 |
114.81 |
<.0001 |
|
week |
-0.00734 |
0.001987 |
1185 |
-3.70 |
0.0002 |
|
week_16 |
-0.01204 |
0.003174 |
1004 |
-3.79 |
0.0002 |
|
week*trt |
0.02685 |
0.003847 |
1534 |
6.98 |
<.0001 |
|
week_16*trt |
-0.02774 |
0.006198 |
1534 |
-4.47 |
<.0001 |