Marginal Logistic Regression Model for Odds of Amenorrhea

Clinical Trial of Contracepting Women

 

The GENMOD Procedure

 

Model Information

Data Set

WORK.AMEN

Distribution

Binomial

Link Function

Logit

Dependent Variable

y

Observations Used

3616

Missing Values

988

 

Class Level Information

Class

Levels

Values

id

1151

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 ...

ctime

4

1 2 3 4

 

Response Profile

Ordered
Value

y

Total
Frequency

1

1

1231

2

0

2385

 

PROC GENMOD is modeling the probability that y='1'.

 

Parameter Information

Parameter

Effect

Prm1

Intercept

Prm2

time

Prm3

time2

Prm4

time*trt

Prm5

time2*trt

 

Criteria For Assessing Goodness Of Fit

Criterion

DF

Value

Value/DF

Deviance

3611

4369.4460

1.2100

Scaled Deviance

3611

4369.4460

1.2100

Pearson Chi-Square

3611

3620.6287

1.0027

Scaled Pearson X2

3611

3620.6287

1.0027

Log Likelihood

 

-2184.7230

 

 

Algorithm converged.

 

Analysis Of Initial Parameter Estimates

Parameter

DF

Estimate

Standard Error

Wald 95% Confidence Limits

Chi-Square

Pr > ChiSq

Intercept

1

-2.1955

0.2059

-2.5991

-1.7920

113.73

<.0001

time

1

0.6698

0.1932

0.2911

1.0485

12.02

0.0005

time2

1

-0.0303

0.0398

-0.1084

0.0478

0.58

0.4468

time*trt

1

0.2973

0.1097

0.0824

0.5122

7.35

0.0067

time2*trt

1

-0.0624

0.0322

-0.1256

0.0007

3.76

0.0526

Scale

0

1.0000

0.0000

1.0000

1.0000

 

 

 

NOTE:

The scale parameter was held fixed.

 

GEE Model Information

Log Odds Ratio Structure

Fully Parameterized Clusters

Within-Subject Effect

ctime (4 levels)

Subject Effect

id (1151 levels)

Number of Clusters

1151

Clusters With Missing Values

437

Correlation Matrix Dimension

4

Maximum Cluster Size

4

Minimum Cluster Size

1

 

Log Odds Ratio Parameter Information

Parameter

Group

Alpha1

(1, 2)

Alpha2

(1, 3)

Alpha3

(1, 4)

Alpha4

(2, 3)

Alpha5

(2, 4)

Alpha6

(3, 4)

 

Algorithm converged.

 

Analysis Of GEE Parameter Estimates

Empirical Standard Error Estimates

Parameter

Estimate

Standard Error

95% Confidence Limits

Z

Pr > |Z|

Intercept

-2.2461

0.1765

-2.5921

-1.9001

-12.72

<.0001

time

0.7030

0.1581

0.3931

1.0129

4.45

<.0001

time2

-0.0323

0.0318

-0.0946

0.0299

-1.02

0.3089

time*trt

0.3380

0.1097

0.1230

0.5529

3.08

0.0021

time2*trt

-0.0683

0.0284

-0.1239

-0.0126

-2.40

0.0162

Alpha1

1.8475

0.1810

1.4928

2.2021

10.21

<.0001

Alpha2

1.4851

0.1985

1.0960

1.8742

7.48

<.0001

Alpha3

1.7605

0.2482

1.2740

2.2471

7.09

<.0001

Alpha4

2.1610

0.1761

1.8159

2.5060

12.27

<.0001

Alpha5

2.0665

0.2034

1.6679

2.4651

10.16

<.0001

Alpha6

2.2783

0.1827

1.9202

2.6364

12.47

<.0001