Marginal Log-linear Regression Model for Leprosy Bacilli

Clinical Trial of Antibiotics for Leprosy

 

The GENMOD Procedure

 

Model Information

Data Set

WORK.LEPROSY

Distribution

Poisson

Link Function

Log

Dependent Variable

y

Observations Used

60

 

Class Level Information

Class

Levels

Values

id

30

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

 

Parameter Information

Parameter

Effect

Prm1

Intercept

Prm2

time

Prm3

time*Antibiotic

 

Criteria For Assessing Goodness Of Fit

Criterion

DF

Value

Value/DF

Deviance

57

207.7285

3.6444

Scaled Deviance

57

207.7285

3.6444

Pearson Chi-Square

57

193.8648

3.4011

Scaled Pearson X2

57

193.8648

3.4011

Log Likelihood

 

712.3139

 

 

Algorithm converged.

 

Analysis Of Initial Parameter Estimates

Parameter

DF

Estimate

Standard Error

Wald 95% Confidence Limits

Chi-Square

Pr > ChiSq

Intercept

1

2.3734

0.0557

2.2641

2.4826

1813.76

<.0001

time

1

0.1362

0.1060

-0.0715

0.3440

1.65

0.1987

time*Antibiotic

1

-0.7691

0.1300

-1.0239

-0.5143

35.00

<.0001

Scale

0

1.0000

0.0000

1.0000

1.0000

 

 

 

NOTE:

The scale parameter was held fixed.

 

GEE Model Information

Correlation Structure

Unstructured

Subject Effect

id (30 levels)

Number of Clusters

30

Correlation Matrix Dimension

2

Maximum Cluster Size

2

Minimum Cluster Size

2

 

Algorithm converged.

 

Working Correlation Matrix

 

Col1

Col2

Row1

1.0000

0.7803

Row2

0.7803

1.0000

 

Analysis Of GEE Parameter Estimates

Empirical Standard Error Estimates

Parameter

Estimate

Standard Error

95% Confidence Limits

Z

Pr > |Z|

Intercept

2.3734

0.0801

2.2163

2.5304

29.62

<.0001

time

-0.0108

0.1572

-0.3189

0.2974

-0.07

0.9455

time*Antibiotic

-0.5141

0.1966

-0.8994

-0.1289

-2.62

0.0089

 

Analysis Of GEE Parameter Estimates

Model-Based Standard Error Estimates

Parameter

Estimate

Standard Error

95% Confidence Limits

Z

Pr > |Z|

Intercept

2.3734

0.1028

2.1718

2.5749

23.08

<.0001

time

-0.0108

0.1142

-0.2345

0.2130

-0.09

0.9249

time*Antibiotic

-0.5141

0.1536

-0.8152

-0.2131

-3.35

0.0008

Scale

1.8454

.

.

.

.

.

 

NOTE:

The scale parameter for GEE estimation was computed as the square root of the normalized Pearson's chi-square.

 

Wald Statistics For Type 3 GEE Analysis

Source

DF

Chi-Square

Pr > ChiSq

time

1

0.00

0.9455

time*Antibiotic

1

6.84

0.0089