Data from a two-period crossover trial on cerebrovascular deficiency. Source: Table 3.1 (page 90) of Jones and Kenward (1989). With permission of CRC Press. Reference: Jones, B. and Kenward, M.G. (1989). Design and Analysis of Cross-over Trials. London: Chapman and Hall/CRC Press. Description: The dataset consists of safety data from a crossover trial on the disease cerebrovascular deficiency. The response variable is not a trial endpoint but rather a potential side effect. In this two-period crossover trial, comparing the effects of active drug to placebo, 67 patients were randomly allocated to the two treatment sequences, with 34 patients receiving placebo followed by active treatment, and 33 patients receiving active treatment followed by placebo. The response variable is binary, indicating whether an electrocardiogram (ECG) was abnormal (Y=1) or normal (Y=0). Each patient has a bivariate binary response vector. Variable List: Subject ID, Sequence (1=Placebo-->Active, 2=Active-->Placebo), Period (0=Period 1, 1=Period 2), TRT (0=Placebo, 1=Active Drug), ECG Response (0=Normal, 1=Abnormal). 1 1 0 0 0 1 1 1 1 0 2 1 0 0 0 2 1 1 1 0 3 1 0 0 0 3 1 1 1 0 4 1 0 0 0 4 1 1 1 0 5 1 0 0 0 5 1 1 1 0 6 1 0 0 0 6 1 1 1 0 7 1 0 0 0 7 1 1 1 0 8 1 0 0 0 8 1 1 1 0 9 1 0 0 0 9 1 1 1 0 10 1 0 0 0 10 1 1 1 0 11 1 0 0 0 11 1 1 1 0 12 1 0 0 0 12 1 1 1 0 13 1 0 0 0 13 1 1 1 0 14 1 0 0 0 14 1 1 1 0 15 1 0 0 0 15 1 1 1 0 16 1 0 0 0 16 1 1 1 0 17 1 0 0 0 17 1 1 1 0 18 1 0 0 0 18 1 1 1 0 19 1 0 0 0 19 1 1 1 0 20 1 0 0 0 20 1 1 1 0 21 1 0 0 0 21 1 1 1 0 22 1 0 0 0 22 1 1 1 0 23 1 0 0 0 23 1 1 1 1 24 1 0 0 0 24 1 1 1 1 25 1 0 0 0 25 1 1 1 1 26 1 0 0 0 26 1 1 1 1 27 1 0 0 0 27 1 1 1 1 28 1 0 0 0 28 1 1 1 1 29 1 0 0 1 29 1 1 1 1 30 1 0 0 1 30 1 1 1 1 31 1 0 0 1 31 1 1 1 1 32 1 0 0 1 32 1 1 1 1 33 1 0 0 1 33 1 1 1 1 34 1 0 0 1 34 1 1 1 1 35 2 0 1 0 35 2 1 0 0 36 2 0 1 0 36 2 1 0 0 37 2 0 1 0 37 2 1 0 0 38 2 0 1 0 38 2 1 0 0 39 2 0 1 0 39 2 1 0 0 40 2 0 1 0 40 2 1 0 0 41 2 0 1 0 41 2 1 0 0 42 2 0 1 0 42 2 1 0 0 43 2 0 1 0 43 2 1 0 0 44 2 0 1 0 44 2 1 0 0 45 2 0 1 0 45 2 1 0 0 46 2 0 1 0 46 2 1 0 0 47 2 0 1 0 47 2 1 0 0 48 2 0 1 0 48 2 1 0 0 49 2 0 1 0 49 2 1 0 0 50 2 0 1 0 50 2 1 0 0 51 2 0 1 0 51 2 1 0 0 52 2 0 1 0 52 2 1 0 0 53 2 0 1 1 53 2 1 0 0 54 2 0 1 1 54 2 1 0 0 55 2 0 1 1 55 2 1 0 0 56 2 0 1 1 56 2 1 0 0 57 2 0 1 0 57 2 1 0 1 58 2 0 1 0 58 2 1 0 1 59 2 0 1 1 59 2 1 0 1 60 2 0 1 1 60 2 1 0 1 61 2 0 1 1 61 2 1 0 1 62 2 0 1 1 62 2 1 0 1 63 2 0 1 1 63 2 1 0 1 64 2 0 1 1 64 2 1 0 1 65 2 0 1 1 65 2 1 0 1 66 2 0 1 1 66 2 1 0 1 67 2 0 1 1 67 2 1 0 1