Department of Biostatistics
HIV Working Group

2023 - 2024

Coordinators: Daniel Xu and Keith Barnatchez

Schedule: Fridays, 1:00-1:50 p.m.
Zoom and Building 2, Room 426 (unless otherwise notified)

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Seminar Description
This working group will focus on statistical issues arising in AIDS research. Sessions will feature presentations on current research related to surveillance methods, clinical trials, and other topics of interest. Student participation is encouraged.

This working group will be meeting hybridly until further notice. The meeting Zoom ID below is a recurring meeting.

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September 8

Michael Hughes, Ph.D.
Professor, Department of Biostatistcs, Harvard T.H. Chan School of Public Health
Director, Center for Biostatistics in AIDS Research

"Intro Session"

September 22

Robert Shapiro, Ph.D.
Principal Research Scientist, Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health

"Early diagnosis and novel HIV treatment strategies for children: results from the EIT, Moso and Tatelo Studies in Botswana"
ABSTRACT: Children living with HIV are ideal candidates for strategies that may lead to post-treatment control following antiretroviral treatment (ART), and those treated from very early life may have unique features that are especially favorable for cure research. With early effective ART, the latent intact HIV reservoir is drastically reduced as the immune system matures through early life. Such children may have the potential for post-treatment control through the outright elimination of intact virus, or its elimination from encoding regions of the genome. This talk will focus on approaches to pediatric treatment and possible post-treatment control that include early diagnosis, early ART, and the use of broadly neutralizing monoclonal antibodies (bNAbs). The talk will review three recent clinical trials in Botswana: the EIT Study, the Moso Study, and the Tatelo Study. The talk will also address the challenges of performing pediatric cure research as well as the unique opportunities to understand avenues to cure offered by pediatric trials.

October 6

Marie-Abele Bind, S.D.
Assistant Professor of Medicine at Harvard Medical School and Assistant Investigator at MGH Biostatistics

"Statistical Methods in the RECOVER Tissue Pathology Study"
ABSTRACT: The goal of the NIH RECOVER Tissue Pathology Study is to define and characterize the epidemiology, natural history, clinical spectrum, and underlying mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC) in a diverse population representative of the general COVID-19 population in the US. We will discuss the aims of the NIH RECOVER Tissue Pathology Study, as well as the associated statistical methods we plan to use.

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Last Update: September 28, 2023