Department of Biostatistics
HIV Working Group
2023 - 2024
ABSTRACT: Children living with HIV are ideal candidates for strategies that may lead to post-treatment control following antiretroviral treatment (ART), and those treated from very early life may have unique features that are especially favorable for cure research. With early effective ART, the latent intact HIV reservoir is drastically reduced as the immune system matures through early life. Such children may have the potential for post-treatment control through the outright elimination of intact virus, or its elimination from encoding regions of the genome. This talk will focus on approaches to pediatric treatment and possible post-treatment control that include early diagnosis, early ART, and the use of broadly neutralizing monoclonal antibodies (bNAbs). The talk will review three recent clinical trials in Botswana: the EIT Study, the Moso Study, and the Tatelo Study. The talk will also address the challenges of performing pediatric cure research as well as the unique opportunities to understand avenues to cure offered by pediatric trials.
ABSTRACT: The goal of the NIH RECOVER Tissue Pathology Study is to define and characterize the epidemiology, natural history, clinical spectrum, and underlying mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC) in a diverse population representative of the general COVID-19 population in the US. We will discuss the aims of the NIH RECOVER Tissue Pathology Study, as well as the associated statistical methods we plan to use.
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Last Update: September 28, 2023